Thyroid News

Abstract  A 44-year-old woman came to medical attention with right thyroid lobe enlargement and weight loss. Thyroid scan and ultrasound
demonstrated a nodule in the right thyroid lobe; a right hemithyroidectomy was performed. Histologic examination documented
granulomatous and lymphocytic thyroiditis associated with a follicular adenoma. No inflammation was apparent within the adenoma.
The parallels between granulomatous thyroiditis and lymphocytic thyroiditis, including presumed viral initiation and deranged

Background: Autoimmune diseases have been implicated in the genesis of MALT lymphoma of various localizations. The development of thyroidal MALT lymphoma has been described as an adverse event in patients suffering from long-standing chronic autoimmune thyroiditis (CAT, Hashimoto's thyroiditis). The percentage and possible association between CAT and extrathyroidal MALT lymphoma, however, have not been assessed so far.

Brain Bioenergetics and Response to Triiodothyronine Augmentation in Major Depressive Disorder Iosifescu DV, Bolo NR, Nierenberg AA, Jensen JE, Fava M, Renshaw PF. Depression Clinical and Research Program, Massachusetts General Hospital, Massachusetts; Brain Imaging Center, McLean Hospital, Harvard Medical School, Boston, Massachusetts. Background: Low cerebral bioenergetic metabolism has been reported in subjects with major depressive disorder (MDD). Thyroid hormones have been shown to increase brain bioenergetic metabolism.

Horm Metab ResDOI: 10.1055/s-2008-1077051AbstractPreviously, a new procedure for measuring serum TSH receptor autoantibodies (TRAb) was reported in which the autoantibodies inhibit binding of a human monoclonal thyroid stimulating antibody M22 to TSHR-coated ELISA plate wells (TRAb ELISA). The aim of the present study was to evaluate the clinical performance of this assay in comparison to the second generation TRAb assay (TRAb LIA) based on the recombinant human TSH-receptor and chemiluminescence technology (TRAb LIA).

Horm Metab Res 2008; 40: 323-328DOI: 10.1055/s-2008-1073155AbstractWith over 2 000 articles published on thyroid cancer between January 1, 2006 and September 10, 2007 it is difficult to offer an updated and complete review on this malignancy. Thus, I elected to summarize papers published in 2007 on topics frequently overlooked in other reviews or books, and papers that are likely to be followed by interesting developments.

Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves’ disease

Genes and Immunity advance online publication, May 1, 2008. doi:10.1038/gene.2008.26

Authors: A A Zeitlin, J M Heward, P R Newby, J D Carr-Smith, J A Franklyn, S C L Gough
& M J Simmonds (Source: Genes and Immunity)  MedWorm Sponsored Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.

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The significance of persistent newly developed autoantibodies in JIA patients under long-term anti-TNF treatment.
Cytokine. 2008 Apr 27;
Authors: Kanakoudi-Tsakalidou F, Tzimouli V, Pratsidou-Gertsi P, Chronopoulou E, Trachana M

Horm Metab ResDOI: 10.1055/s-2008-1073151AbstractChemokines are a group of small proteins that recruit different leukocyte subtypes to sites of inflammation and play important roles in initiating and maintaining immunological responses in autoimmune endocrine diseases including Graves’ disease (GD) and Hashimoto's thyroiditis (HT). Previous studies have found increased gene and protein expression of different kinds of chemokines not only within the thyroid gland but also within thyroid cells in GD or HT patients.

Abstract  Herein we present the case of a 9-year-old girl who had an enlarged right lobe of the thyroid gland and sub-clinical hypothyroidism
(thyroid stimulating hormone at 9.24 mIU/L). The patient had a history of unintentional exposure to radiation while her mother
was receiving radionuclide therapy for diffuse toxic goiter. Ultrasonography of the young girl showed right lobe enlargement
with diffuse coarse heterogenous echogenicity, compatible with a microcalcification pattern identified in both lobes of the

Thyroid , Vol. 0, No. 0. (Source: Thyroid)