Thyroid News

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Thyroid Function and Structure Are Affected in Childhood Obesity.
J Clin Endocrinol Metab. 2008 Oct 7;
Authors: Radetti G, Kleon W, Buzi F, Crivellaro C, Pappalardo L, di Iorgi N, Maghnie M

Horm Res 2008;70:278-284 (DOI:10.1159/000157874) (Source: Hormone Research)  MedWorm Sponsored Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.

p53 protein participates in the processes of apoptosis, which is involved in a number of immunological reactions. In order to test whether the p53 gene could be used as a genetic marker for the prediction of the development of autoimmune thyroid diseases (AITD), we screened, by using polymerase chain reaction (PCR) analysis, for the C (CC_C)/G (CG_C) polymorphism at the p53 codon 72 (Pro 72/Arg 72) to determine the genotypes of 107 Hashimoto's thyroiditis (HT) and 90 Graves' disease (GD) patients, and 105 normal controls.

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p53 codon 72 proline/arginine polymorphism and autoimmune thyroid diseases.
J Clin Lab Anal. 2008 Sep 19;22(5):321-326

Hashimoto's thyroiditis (HT) is associated with HLA, but the associated allele is still controversial. We hypothesized that specific HLA-DR pocket-sequence... (Source: Proceedings of the National Academy of Sciences)  MedWorm Sponsored Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.

Viral Immunology Sep 2008, Vol. 21, No. 3: 379-384.

Hashimoto's thyroiditis is a common autoimmune disorder of the thyroid gland. It has been linked to infections with hepatitis C, EBV, HTLV-1, and Yersinia enterocolitica. As parvovirus B19 has been associated with a wide spectrum of autoimmune diseases, ... (Source: Viral Immunology)  MedWorm Sponsored Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.

Exp Clin Endocrinol Diabetes 2008; 116: S59-S63DOI: 10.1055/s-2008-1081491AbstractThyrotropin receptor (TSHR) antibody (TRAb) assays based on human or porcine TSHR which are coated to a solid phase are the most commonly used detection methods in clinical practice for patients with thyroid diseases. Yet the difference of the diagnostic values of the two TRAb assays is largely unclear.

The mechanism of disease progression in Hashimoto's thyroiditis (HT) is still unclear. Anti-thyroid peroxidase antibody (TPOAb), a diagnostic hallmark of HT, is principally of the immunoglobulin G (IgG) isotype, and it appears to be a response to thyroid injury. The aim of our study was to evaluate the distribution of IgG subclasses of TPOAb in sera from patients with HT with different thyroid functional status.

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Genetic Testing Sep 2008, Vol. 12, No. 3: 461-464.

Two common forms of autoimmune thyroid diseases are Graves' disease and Hashimoto's thyroiditis. Cytotoxic T lymphocyte antigen 4 (CTLA4) encoded by the CTLA4 gene on chromosome 2q33 plays a role in susceptibility to Graves' disease and is probably ... (Source: Genetic Testing)  MedWorm Sponsored Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.