Intraoperative parathyroid hormone levels measured by intact and whole parathyroid hormone assays in patients with graves’ disea

Abstract
Purpose  To find out if the whole parathyroid hormone (wPTH) assay has practical advantages over the intact (iPTH) assay in patients
with Graves’ disease.

Methods  We measured iPTH and wPTH levels before and after subtotal thyroidectomy in 111 consecutive patients (94 women and 17 men)
with Graves’ disease. Blood samples for assays were obtained after the induction of anesthesia (basal) and following skin
closure (postoperative).

Results  There was a significant correlation between wPTH and iPTH in both the basal and postoperative levels. Logistic regression
analyses examining the relationship between the reduction in parathyroid hormone (PTH) levels and the incidence of tetany
revealed that both the wPTH and iPTH assays were significantly equally predictive of postoperative tetany.

Conclusion  We found that both the wPTH and iPTH assays were useful for predicting postoperative tetany in patients with Graves’ disease,
yielding similar results.

Content Type Journal ArticleCategory Original ArticlesDOI 10.1007/s00595-007-3597-2Authors
Masaya Kai, Noguchi Thyroid Clinic and Hospital Foundation Beppu, Oita JapanHiroyuki Yamashita, Noguchi Thyroid Clinic and Hospital Foundation Beppu, Oita JapanTom Cantor, Scantibodies Laboratory Inc. Santee CA USATaiki Moriyama, Noguchi Thyroid Clinic and Hospital Foundation Beppu, Oita JapanMasae Rai, Noguchi Thyroid Clinic and Hospital Foundation Beppu, Oita JapanTakahiro Ogawa, Noguchi Thyroid Clinic and Hospital Foundation Beppu, Oita JapanShin Watanabe, Noguchi Thyroid Clinic and Hospital Foundation Beppu, Oita JapanShinya Uchino, Noguchi Thyroid Clinic and Hospital Foundation Beppu, Oita JapanShiro Noguchi, Noguchi Thyroid Clinic and Hospital Foundation Beppu, Oita Japan

Journal Surgery TodayOnline ISSN 1436-2813Print ISSN 0941-1291

Journal Volume Volume 38

Journal Issue Volume 38, Number 3 / March, 2008 (Source: Surgery Today)