Effectiveness of peripheral thyrotropin receptor mrna in follow-up of differentiated thyroid cancer

We examined the utility of TSHR mRNA
in long-term follow-up of TC patients. From 2002 to 2007, TSHR mRNA was prospectively measured by quantitative reverse-transcription
polymerase chain reaction (RT-PCR) from peripheral blood samples in 259 patients, and those followed ≥3 months since initial
thyroidectomy were studied. TSHR mRNA levels were correlated to thyroglobulin (Tg), imaging studies, and disease status during
follow-up. Thirty-four patients underwent 20 ± 14 months median follow-up for papillary (n = 31, 91%), follicular (n = 2) or Hurthle cell (n = 1) TC. Advanced-stage disease occurred in 24% at presentation, and 11 (32%) developed cervical node metastases or recurrence
requiring reoperation during follow-up. Of 52 simult... MedWorm Sponsored Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.