Multinodular goiter and primary hyperparathyroidism: a circuitous route to diagnosing metastatic uveal melanoma

Abstract  Uveal melanoma spreads exclusively via a hematogenous route and is notable for its latency. Liver metastases are common; however,
metastatic spread to unusual sites has been encountered. We report the case of metastatic uveal melanoma in a woman with multinodular
goiter and primary hyperparathyroidism. The patient presented with hypercalcemia and an elevated intact parathyroid hormone
level, in conjunction with a follicular neoplasm in the setting of goiter. She underwent an uneventful total thyroidectomy
and parathyroidectomy. Postoperatively, she became normocalcemic. Histopathologic analyses revealed metastatic uveal melanoma
cells within both the multinodular goiter and parathyroid adenoma. At present, she is enrolled in a phase II trial for disseminated
uveal melanoma. This is a report of uveal melanoma metastatic to both a parathyroid adenoma and a nodular hyperplastic thyroid.
Additionally, this case serves to display the unusual metastatic potential of uveal melanoma.

Content Type Journal ArticleDOI 10.1007/s12022-008-9041-3Authors
Constantine G. A. Theoharis, Yale University School of Medicine Department of Pathology New Haven CT USATobias Carling, Yale University School of Medicine Department of Surgery 333 Cedar Street New Haven CT 06520 USANatalia Buza, Yale University School of Medicine Department of Pathology New Haven CT USAEduardo Zambrano, Yale University School of Medicine Department of Pathology New Haven CT USAJulie Ann Sosa, Yale University School of Medicine Department of Surgery 333 Cedar Street New Haven CT 06520 USA

Journal Endocrine PathologyOnline ISSN 1559-0097Print ISSN 1046-3976 (Source: Endocrine Pathology)  MedWorm Sponsored Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.