The detection of antithyroglobulin activity in human serum monoclonal immunoglobulins (monoclonal gammopathies)

Abstract  The sera of 159 patients with monoclonal gammopathies were examined for the presence of anti-thyroglobulin (Tg) activity.
An enzyme-linked immunosorbent assay was employed. Thirty-one (19.5%) sera were found to bind Tg. The activity against Tg
was further confirmed by using purified immunoglobulins and employing competition assays. The anti-Tg antibodies were found
in the sera of patients with IgG, IgM and IgA gammopathies. Anti-Tg antibodies were more frequent among patients with IgG
gammopathy. Autoantibodies to Tg are found in patients with Hashimoto's thyroiditis, Graves' disease and occasionally in patients
with thyroid carcinoma. Natural autoantibodies directed against human Tg have been detected, as well, in healthy subjects.
None of the patients in the present study whose serum was found to contain high titers of anti-Tg human monoclonal antibodies
had any clinical or biochemical evidence of thyroid disease. Our results of a high incidence of anti-Tg activity in the sera
of patients with monoclonal gammopathies support previous reports of autoantibody properties characteristic of these immunoglobulins.

Content Type Journal ArticleDOI 10.1007/BF02935506Authors
N. Yativ, Sheba Medical Center Department of Medicine B, Research Unit of Autoimmune Diseases 52621 Tel-Hashomer (Israel)D. Buskila, Sheba Medical Center Department of Medicine B, Research Unit of Autoimmune Diseases 52621 Tel-Hashomer (Israel)M. Blank, Sheba Medical Center Department of Medicine B, Research Unit of Autoimmune Diseases 52621 Tel-Hashomer (Israel)C. L. Burek, Johns Hopkins University School of Hygiene and Public Health Department of Immunology and Infectious Diseases Baltimore Md. USAN. R. Rose, Johns Hopkins University School of Hygiene and Public Health Department of Immunology and Infectious Diseases Baltimore Md. USAY. Shoenfeld, Sheba Medical Center Department of Medicine B, Research Unit of Autoimmune Diseases 52621 Tel-Hashomer (Israel)

Journal Immunologic ResearchOnline ISSN 1559-0755Print ISSN 0257-277X

Journal Volume Volume 12

Journal Issue Volume 12, Number 4 / December, 1993 (Source: Immunologic Research)  MedWorm Sponsored Message: Find out how you can get your message across here by sponsoring this MedWorm news feed.