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 Thursday February 09, 2012       10:24 pm
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Molecular detection of pparγ rearrangements and thyroid carcinoma in preoperative fine-needle aspiration biopsies

Abstract  The pathologic diagnosis of thyroid follicular tumors is difficult, particularly in preoperative fine-needle aspiration biopsies.
To investigate whether the molecular diagnosis of PPARγ rearrangements can detect thyroid carcinomas in fine-needle aspiration biopsies, we performed interphase fluorescence in
situ hybridization on 24 thyroid fine-needle aspiration and 17 follow-up thyroidectomy specimens. Two of the 24 fine-needle

Two patients with metastasis of cancer to other neoplasm: a thyroid carcinoma metastatic to a lung carcinoma and a gastric carci

Abstract  Two patients with rare cancer-to-neopiasm metastasis are presented. One patient was a 69-year-old woman who had undergone
gastrectomy for gastric cancer 10 months previously and died of generalized metastases. An autopsy revealed generalized metastases
of the gastric carcinoma, together with a cystic, hemorrhagic thyroid tumor measuring 2.0 cm in diameter. Histologically,
the thyroid tumor was an oxyphilic adenoma with multiple metastatic foci of gastric adenocarcinoma. Because no metastasis

The detection of antithyroglobulin activity in human serum monoclonal immunoglobulins (monoclonal gammopathies)

Abstract  The sera of 159 patients with monoclonal gammopathies were examined for the presence of anti-thyroglobulin (Tg) activity.
An enzyme-linked immunosorbent assay was employed. Thirty-one (19.5%) sera were found to bind Tg. The activity against Tg
was further confirmed by using purified immunoglobulins and employing competition assays. The anti-Tg antibodies were found
in the sera of patients with IgG, IgM and IgA gammopathies. Anti-Tg antibodies were more frequent among patients with IgG

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