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Abstract  During the second century A.D., Galen described a nerve that came from the brain on each side of the neck, went down toward
the heart, and then reversed course and ascended to the larynx and caused the vocal cords to open. He called these “reversivi”
(or recurrent nerves) and stated that he was the first to discover “these wonderful things.” Demonstrating before the elders
of Rome, he showed that cutting the recurrent laryngeal nerve in the neck caused a live pig to stop squealing—an extraordinary

CONCLUSION: This study indicates that TGF-beta1, VEGF and NO probably have a role in the pathogenesis of Hashimoto's thyroiditis, and development of autoimmunity. Clearly, further studies are necessary to establish the exact mechanism of TGF-beta1, VEGF and NO interaction in Hashimoto's thyroiditis.
PMID: 19028605 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)