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A multi-center research team have shown that the addition of the thyroid hormone liothyronine (Cytomel®) improved the response to the SSRI antidepressant sertraline (Zoloft®) in patients with major depressive disorder. While there is a significant body of medical opinion in favor of adding a thyroid hormone to standard antidepressive drug treatment in patients with major depression, especially those who have not responded to the antidepressive drug alone, this mode of therapy is still controversial.

Thyroid hormone replacement therapy may not resolve hypothyroid linked mood swings Hypothyroidism is often associated with mood changes like depression and lethargy. Researchers, studying underlying brain processes in search of "why" this happens, have reported their results at the 54th Annual Meeting of SNM, the world's largest society for molecular imaging and nuclear medicine professionals.